[Clinical research of Ibudilast on treating the steroid resistant allergic rhinitis] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery [Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] Journal article | | Title | [Clinical research of Ibudilast on treating the steroid resistant allergic rhinitis] | | Author(s) | Luo H, Tao Z, Yan N, Liang J, Wang P, Wang J | | Institution | Department of Otorhinolaryngology, the Central Hospital of Xiangfan City, Xiangfan, 441021, China. lh07103999370@163.com | | Source | Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009 Jan; 23(2):63-6. | | Abstract | OBJECTIVE: To compare the efficacy and safety of histamine H1 receptor antagonist loratadine with Leukotriene receptor antagonist Ibudilast in steroid resistant allergic rhinitis in a randomized controlled clinical trial.
METHOD: Thirty-five cases were treated by Ibudilast, and 34 cases by loratadine. Score system was used to compare the therapeutic effect of these two drugs on clinical symptoms and signs.
RESULT: Ibudilast shows a better curative effect than loratadine in the improvement of the total scores on clinical symptom and signs(P<0.05). Scores of symptoms and signs in Ibudilast group after 3, 7, 14 days decreased significantly by means of square analysis of single factor (P<0.01). No complication was observed.
CONCLUSION: Ibudilast can effectively alleviate the clinical symptoms and signs of steroid resistant allergic rhinitis with confirmed efficacy and safety, thus is recommended in steroid resistant allergic rhinitis. Increased doses or prolonged treatment of steroid is inappropriate. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19452709 |
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